Mitosis: KLP61F Goes Wee!
نویسندگان
چکیده
منابع مشابه
Mitosis: KLP61F Goes Wee!
Kinesin-5s help assemble the bipolar spindle by crosslinking and sliding apart antiparallel microtubules. A recent study has uncovered a novel pathway for the phospho-regulation of these motors.
متن کاملThe kinesin-like protein KLP61F is essential for mitosis in Drosophila
We report here that disruption of a recently discovered kinesin-like protein in Drosophila melanogaster, KLP61F, results in a mitotic mutation lethal to the organism. We show that in the absence of KLP61F function, spindle poles fail to separate, resulting in the formation of monopolar mitotic spindles. The resulting phenotype of metaphase arrest with polyploid cells is reminiscent of that seen...
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We prove that longest common prefix (LCP) information can be stored in much less space than previously known. More precisely, we show that in the presence of the text and the suffix array, o(n) additional bits are sufficient to answer LCP-queries asymptotically in the same time that is needed to retrieve an entry from the suffix array. This yields the smallest compressed suffix tree with sublog...
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By mid-afternoon, after your orthopedic adventures, after postop rounds, and a couple of labor epidurals, it’s time to make out Monday’s OR schedule. But, you don’t have enough “providers” to staff all the ORs. So, you make phone call after phone call, hoping to enlist some help (otherwise, you might not make it home tomorrow). Then, the ICU calls. Can you please intubate someone? Next, the ER ...
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CommenTAry CommenTAry I t has been known for many years that manipulation of cell cycle checkpoint function represents one approach by which the toxicity of chemotherapy and of ionizing radiation can be increased in tumor cells. The mitotic cell cycle checkpoint is regulated by the kinase CDK1, which in turn is regulated by both ATM/ATR-CHK1/2-CDC25C signaling and by the tyrosine kinase WEE1. H...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2009
ISSN: 0960-9822
DOI: 10.1016/j.cub.2009.09.003